Endocrine Abstracts

Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH...

Loss-of-function mutations in the TSH receptor (TSHR) gene are one of the most common known causes of congenital hypothyroidism (CH). While heterozygous mutations result in nonautoimmune isolated hyperthyrotropinemia, homozygous and compound heterozygous mutations may cause overt CH of various severity depending on the localization and type of the mutations.In our study we performed the systematic genetic analysis of the TSHR gene of a cohort of 85 Hunga...

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

Drug-induced vasculitis or lupus-like syndromes can complicate the clinical course of PTU-treated patients. The clinical manifestations of four patients treated with PTU for Graves’ disease are presented.A 37-year-old woman was treated with PTU for six years. She had severe thyrotoxicosis, high fever and polyarthralgia. Elevated doses of PTU resulted in normalization of thyroid function, but the fever and arthralgia persisted even after steroid admi...